BLASTP 2.2.5 [Nov-16-2002]
Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= ci0100131222
(303 letters)
Database: All non-redundant GenBank CDS
translations+PDB+SwissProt+PIR+PRF excluding environmental samples
1,798,171 sequences; 593,787,773 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|41056229|ref|NP_956409.1| anterior pharynx defective 1B ... 187 2e-46
gi|20129183|ref|NP_608710.1| CG2855-PA [Drosophila melanoga... 171 2e-41
gi|12654775|gb|AAH01230.1| APH-1A protein [Homo sapiens] 167 3e-40
gi|34858248|ref|XP_345252.1| similar to Aph1a-pending prote... 166 4e-40
gi|37077707|sp|Q96BI3|AP1A_HUMAN Gamma-secretase subunit AP... 166 5e-40
gi|14250557|gb|AAH08732.1| APH-1A protein [Homo sapiens] >g... 166 5e-40
gi|7705787|ref|NP_057106.1| CGI-78 protein [Homo sapiens] >... 166 7e-40
gi|22203751|ref|NP_666216.1| anterior pharynx defective 1A ... 165 1e-39
gi|37077149|sp|Q8BVF7|AP1A_MOUSE Gamma-secretase subunit AP... 165 1e-39
gi|29243936|ref|NP_808251.1| hypothetical protein 4632417K0... 161 2e-38
gi|34864291|ref|XP_217185.2| similar to RIKEN cDNA 0610008A... 160 2e-38
gi|31233667|ref|XP_318923.1| ENSANGP00000015809 [Anopheles ... 160 3e-38
gi|21492616|ref|NP_080950.1| RIKEN cDNA 0610008A10 [Mus mus... 160 3e-38
gi|18088649|gb|AAH20905.1| Presenilin stabilization factor-... 155 7e-37
gi|37182518|gb|AAQ89061.1| TAAV688 [Homo sapiens] 155 1e-36
gi|13775224|ref|NP_112591.1| presenilin stabilization facto... 154 2e-36
gi|26347159|dbj|BAC37228.1| unnamed protein product [Mus mu... 112 7e-24
gi|26324468|dbj|BAC25988.1| unnamed protein product [Mus mu... 108 2e-22
gi|34864287|ref|XP_343418.1| similar to RIKEN cDNA 0610008A... 96 1e-18
gi|42661244|ref|XP_375430.1| similar to 60S ribosomal prote... 89 8e-17
gi|38091510|ref|XP_358407.1| RIKEN cDNA 1810012P15 [Mus mus... 88 2e-16
gi|18402667|ref|NP_565724.1| expressed protein [Arabidopsis... 79 9e-14
gi|21594204|gb|AAM65980.1| unknown [Arabidopsis thaliana] 79 1e-13
gi|39580694|emb|CAE70374.1| Hypothetical protein CBG16933 [... 69 2e-10
gi|17509423|ref|NP_492469.1| i-78 protein like, Anterior PH... 68 3e-10
gi|20829201|ref|XP_129583.1| similar to CGI-78 protein [Mus... 51 3e-05
>gi|41056229|ref|NP_956409.1| anterior pharynx defective 1B [Danio rerio]
gi|37077309|sp|Q8JHE9|AP1B_BRARE Gamma-secretase subunit Aph-1b (Anterior-pharynx-defective protein
1b)
gi|22001127|gb|AAM88325.1| Aph-1 protein [Danio rerio]
gi|37682171|gb|AAQ98012.1| anterior pharynx defective 1B-like [Danio rerio]
Length = 258
Score = 187 bits (475), Expect = 2e-46
Identities = 99/247 (40%), Positives = 144/247 (58%), Gaps = 13/247 (5%)
Query: 66 MPLMVFFGCTMIAFGPSLAMFILTIAKYPLKIILLVVGXXXXXXXXXXXXXXXXXVVPLK 125
M + VFFGCT IAFGP++A+F+ TIA+ PL++I L+ G V +
Sbjct: 1 MTVAVFFGCTFIAFGPAIALFMFTIARDPLRVIFLIAGAFFWLVSLLLSSLVWFITVQIS 60
Query: 126 EQ---------LAFSLVFSVIFQEGMRYGLFRMMKNAENGLDDALSEDEKKSISNHKLSY 176
+ L F +V SV+ QE RYG +R++K A GL ALS+++ IS +L+Y
Sbjct: 61 NKNSATQQRGLLIFGVVLSVLLQEAFRYGYYRLLKKANEGLL-ALSQEDTMPISMRQLAY 119
Query: 177 TTGFGFGLMYGLFSIVNVLSQSIGPGSVGIDGHSSNFMLISAFLTSSTILLHTFWNVIVF 236
+G GFG M G FS+VN+LS S+GPG+VGI G S ++ + SAF+T + ILLH FW V+ F
Sbjct: 120 VSGLGFGFMSGAFSVVNILSDSLGPGTVGIHGESQHYFISSAFMTLAIILLHMFWGVVFF 179
Query: 237 DALNKQQYYKVITVVCLHMLVSCCSLLNVQQNLAXXXXXXXXXXLIGTTVWAFKAAGGSV 296
+A +Q+++ + VV H++VSC + +N L VWA+ AGGS+
Sbjct: 180 EACERQRWWALGAVVASHLVVSCLTFVNPHYQ---GSLIPTYIILSVMAVWAYLCAGGSL 236
Query: 297 VNIKSCL 303
N+K CL
Sbjct: 237 RNLKLCL 243
>gi|20129183|ref|NP_608710.1| CG2855-PA [Drosophila melanogaster]
gi|37077998|sp|Q9VQG2|APH1_DROME Gamma-secretase subunit Aph-1 (Presenilin stabilization factor)
gi|7295913|gb|AAF51212.1| CG2855-PA [Drosophila melanogaster]
gi|15291627|gb|AAK93082.1| LD12037p [Drosophila melanogaster]
gi|24637560|gb|AAN63815.1| presenilin stabilization factor [Drosophila melanogaster]
Length = 238
Score = 171 bits (433), Expect = 2e-41
Identities = 95/230 (41%), Positives = 137/230 (59%), Gaps = 3/230 (1%)
Query: 66 MPLMVFFGCTMIAFGPSLAMFILTIAKYPLKIILLVVGXXXXXXXXXXXXXXXXXVVPLK 125
M L FFGCT IAFGP A+F+ TIA P++II+L+ ++PLK
Sbjct: 1 MTLPEFFGCTFIAFGPPFALFVFTIANDPVRIIILIAAAFFWLLSLLISSLWYA-LIPLK 59
Query: 126 EQLAFSLVFSVIFQEGMRYGLFRMMKNAENGLDDALSEDEKKSISNHKLSYTTGFGFGLM 185
E LAF +VFSV FQE RY ++R++++ E GL A++ED + + + H L+Y +G GFG++
Sbjct: 60 EFLAFGVVFSVCFQEAFRYIIYRILRSTEQGLH-AVAEDTRVTDNKHILAYVSGLGFGII 118
Query: 186 YGLFSIVNVLSQSIGPGSVGIDGHSSNFMLISAFLTSSTILLHTFWNVIVFDALNKQQYY 245
G+F++VNVL+ GPG++G+ G + F + SA S ILLHTFW+VI F+A + Y
Sbjct: 119 SGMFALVNVLADMSGPGTMGLKGGTELFFVTSAAQALSIILLHTFWSVIFFNAFDTNNYI 178
Query: 246 KVITVVCLHMLVSCCSLLNVQQNLAXXXXXXXXXXLIGTTVWAFKAAGGS 295
+ VV H+ VS +LLN + L I T V AF+ AGG+
Sbjct: 179 HIGYVVFSHLFVSLITLLNANE-LYTTTLLINYLVTILTGVLAFRVAGGT 227
>gi|12654775|gb|AAH01230.1| APH-1A protein [Homo sapiens]
Length = 265
Score = 167 bits (422), Expect = 3e-40
Identities = 90/247 (36%), Positives = 142/247 (57%), Gaps = 13/247 (5%)
Query: 66 MPLMVFFGCTMIAFGPSLAMFILTIAKYPLKIILLVVGXXXXXXXXXXXXXXXXXVVPLK 125
M VFFGCT +AFGP+ A+F++T+A PL++I+LV G +V +
Sbjct: 1 MGAAVFFGCTFVAFGPAFALFLITVAGDPLRVIILVAGAFFWLVSLLLASVVWFILVHVT 60
Query: 126 EQ---------LAFSLVFSVIFQEGMRYGLFRMMKNAENGLDDALSEDEKKSISNHKLSY 176
++ L F SV+ QE R+ ++++K A+ GL +LSED + IS +++Y
Sbjct: 61 DRSDARLQYGLLIFGAAVSVLLQEVFRFAYYKLLKKADEGLA-SLSEDGRSPISIRQMAY 119
Query: 177 TTGFGFGLMYGLFSIVNVLSQSIGPGSVGIDGHSSNFMLISAFLTSSTILLHTFWNVIVF 236
+G FG++ G+FS++N+L+ ++GPG VGI G S + L SAFLT++ ILLHTFW V+ F
Sbjct: 120 VSGLSFGIISGVFSVINILADALGPGVVGIHGDSPYYFLTSAFLTAAIILLHTFWGVVFF 179
Query: 237 DALNKQQYYKVITVVCLHMLVSCCSLLNVQQNLAXXXXXXXXXXLIGTTVWAFKAAGGSV 296
DA +++Y+ + VV H+L S + LN + + +WAF AGGS+
Sbjct: 180 DACERRRYWALGLVVGSHLLTSGLTFLNPWYEASLLPIYAVT---VSMGLWAFITAGGSI 236
Query: 297 VNIKSCL 303
+I+ L
Sbjct: 237 RSIQRSL 243
>gi|34858248|ref|XP_345252.1| similar to Aph1a-pending protein [Rattus norvegicus]
Length = 265
Score = 166 bits (421), Expect = 4e-40
Identities = 90/247 (36%), Positives = 142/247 (57%), Gaps = 13/247 (5%)
Query: 66 MPLMVFFGCTMIAFGPSLAMFILTIAKYPLKIILLVVGXXXXXXXXXXXXXXXXXVVPLK 125
M VFFGCT +AFGP+ A+F++T+A PL++I+LV G +V +
Sbjct: 1 MGAAVFFGCTFVAFGPAFALFLITVAGDPLRVIILVAGAFFWLVSLLLASVVWFILVHVT 60
Query: 126 EQ---------LAFSLVFSVIFQEGMRYGLFRMMKNAENGLDDALSEDEKKSISNHKLSY 176
++ L F SV+ QE R+ ++++K A+ GL +LSED + IS +++Y
Sbjct: 61 DRSDARLQYGLLIFGAAVSVLLQEVFRFAYYKLLKKADEGLA-SLSEDGRSPISIRQMAY 119
Query: 177 TTGFGFGLMYGLFSIVNVLSQSIGPGSVGIDGHSSNFMLISAFLTSSTILLHTFWNVIVF 236
+G FG++ G+FS++N+L+ ++GPG VGI G S + L SAFLT++ ILLHTFW V+ F
Sbjct: 120 VSGLSFGIISGVFSVINILADALGPGVVGIHGDSPYYFLTSAFLTAAIILLHTFWGVVFF 179
Query: 237 DALNKQQYYKVITVVCLHMLVSCCSLLNVQQNLAXXXXXXXXXXLIGTTVWAFKAAGGSV 296
DA +++Y+ + VV H+L S + LN + + +WAF AGGS+
Sbjct: 180 DACERRRYWALGLVVGSHLLTSGLTFLNPWYEASLLPIYAVT---VSMGLWAFVTAGGSL 236
Query: 297 VNIKSCL 303
+I+ L
Sbjct: 237 RSIQRSL 243
>gi|37077707|sp|Q96BI3|AP1A_HUMAN Gamma-secretase subunit APH-1A (APH-1a) (Aph-1alpha) (Presenilin
stabilization factor) (CGI-78) (UNQ579/PRO1141)
gi|15990414|gb|AAH15568.1| APH-1A protein [Homo sapiens]
gi|18088501|gb|AAH20590.1| APH-1A protein [Homo sapiens]
gi|25989510|gb|AAM61956.1| presenilin stabilization factor b [Homo sapiens]
Length = 265
Score = 166 bits (420), Expect = 5e-40
Identities = 90/247 (36%), Positives = 142/247 (57%), Gaps = 13/247 (5%)
Query: 66 MPLMVFFGCTMIAFGPSLAMFILTIAKYPLKIILLVVGXXXXXXXXXXXXXXXXXVVPLK 125
M VFFGCT +AFGP+ A+F++T+A PL++I+LV G +V +
Sbjct: 1 MGAAVFFGCTFVAFGPAFALFLITVAGDPLRVIILVAGAFFWLVSLLLASVVWFILVHVT 60
Query: 126 EQ---------LAFSLVFSVIFQEGMRYGLFRMMKNAENGLDDALSEDEKKSISNHKLSY 176
++ L F SV+ QE R+ ++++K A+ GL +LSED + IS +++Y
Sbjct: 61 DRSDARLQYGLLIFGAAVSVLLQEVFRFAYYKLLKKADEGLA-SLSEDGRSPISIRQMAY 119
Query: 177 TTGFGFGLMYGLFSIVNVLSQSIGPGSVGIDGHSSNFMLISAFLTSSTILLHTFWNVIVF 236
+G FG++ G+FS++N+L+ ++GPG VGI G S + L SAFLT++ ILLHTFW V+ F
Sbjct: 120 VSGLSFGIISGVFSVINILADALGPGVVGIHGDSPYYFLTSAFLTAAIILLHTFWGVVFF 179
Query: 237 DALNKQQYYKVITVVCLHMLVSCCSLLNVQQNLAXXXXXXXXXXLIGTTVWAFKAAGGSV 296
DA +++Y+ + VV H+L S + LN + + +WAF AGGS+
Sbjct: 180 DACERRRYWALGLVVGSHLLTSGLTFLNPWYEASLLPIYAVT---VSMGLWAFITAGGSL 236
Query: 297 VNIKSCL 303
+I+ L
Sbjct: 237 RSIQRSL 243
>gi|14250557|gb|AAH08732.1| APH-1A protein [Homo sapiens]
gi|14550502|gb|AAH09501.1| APH-1A protein [Homo sapiens]
gi|17389295|gb|AAH17699.1| APH-1A protein [Homo sapiens]
gi|22761292|dbj|BAC11529.1| unnamed protein product [Homo sapiens]
gi|25989508|gb|AAM61955.1| presenilin stabilization factor a [Homo sapiens]
gi|37183020|gb|AAQ89310.1| GAAV579 [Homo sapiens]
Length = 247
Score = 166 bits (420), Expect = 5e-40
Identities = 90/247 (36%), Positives = 142/247 (57%), Gaps = 13/247 (5%)
Query: 66 MPLMVFFGCTMIAFGPSLAMFILTIAKYPLKIILLVVGXXXXXXXXXXXXXXXXXVVPLK 125
M VFFGCT +AFGP+ A+F++T+A PL++I+LV G +V +
Sbjct: 1 MGAAVFFGCTFVAFGPAFALFLITVAGDPLRVIILVAGAFFWLVSLLLASVVWFILVHVT 60
Query: 126 EQ---------LAFSLVFSVIFQEGMRYGLFRMMKNAENGLDDALSEDEKKSISNHKLSY 176
++ L F SV+ QE R+ ++++K A+ GL +LSED + IS +++Y
Sbjct: 61 DRSDARLQYGLLIFGAAVSVLLQEVFRFAYYKLLKKADEGLA-SLSEDGRSPISIRQMAY 119
Query: 177 TTGFGFGLMYGLFSIVNVLSQSIGPGSVGIDGHSSNFMLISAFLTSSTILLHTFWNVIVF 236
+G FG++ G+FS++N+L+ ++GPG VGI G S + L SAFLT++ ILLHTFW V+ F
Sbjct: 120 VSGLSFGIISGVFSVINILADALGPGVVGIHGDSPYYFLTSAFLTAAIILLHTFWGVVFF 179
Query: 237 DALNKQQYYKVITVVCLHMLVSCCSLLNVQQNLAXXXXXXXXXXLIGTTVWAFKAAGGSV 296
DA +++Y+ + VV H+L S + LN + + +WAF AGGS+
Sbjct: 180 DACERRRYWALGLVVGSHLLTSGLTFLNPWYEASLLPIYAVT---VSMGLWAFITAGGSL 236
Query: 297 VNIKSCL 303
+I+ L
Sbjct: 237 RSIQRSL 243
>gi|7705787|ref|NP_057106.1| CGI-78 protein [Homo sapiens]
gi|4929623|gb|AAD34072.1| CGI-78 protein [Homo sapiens]
gi|24637562|gb|AAN63816.1| presenilin stabilization factor [Homo sapiens]
Length = 251
Score = 166 bits (419), Expect = 7e-40
Identities = 91/249 (36%), Positives = 144/249 (57%), Gaps = 15/249 (6%)
Query: 66 MPLMVFFGCTMIAFGPSLAMFILTIAKYPLKIILLVVGXXXXXXXXXXXXXXXXXVVPLK 125
M VFFGCT +AFGP+ A+F++T+A PL++I+LV G +V +
Sbjct: 1 MGAAVFFGCTFVAFGPAFALFLITVAGDPLRVIILVAGAFFWLVSLLLASVVWFILVHVT 60
Query: 126 EQ---------LAFSLVFSVIFQEGMRYGLFRMMKNAENGLDDALSEDEKKSISNHKLSY 176
++ L F SV+ QE R+ ++++K A+ GL +LSED + IS +++Y
Sbjct: 61 DRSDARLQYGLLIFGAAVSVLLQEVFRFAYYKLLKKADEGLA-SLSEDGRSPISIRQMAY 119
Query: 177 TTGFGFGLMYGLFSIVNVLSQSIGPGSVGIDGHSSNFMLISAFLTSSTILLHTFWNVIVF 236
+G FG++ G+FS++N+L+ ++GPG VGI G S + L SAFLT++ ILLHTFW V+ F
Sbjct: 120 VSGLSFGIISGVFSVINILADALGPGVVGIHGDSPYYFLTSAFLTAAIILLHTFWGVVFF 179
Query: 237 DALNKQQYYKVITVVCLHMLVSCCSLLNVQQNLAXXXXXXXXXXLIGTTVWAFKAAGGSV 296
DA +++Y+ + VV H+L S + LN + + +WAF AGGS+
Sbjct: 180 DACERRRYWALGLVVGSHLLTSGLTFLNPWYEASLLPIYAVT---VSMGLWAFITAGGSL 236
Query: 297 VNIK--SCL 303
+I+ SC+
Sbjct: 237 RSIQRSSCV 245
>gi|22203751|ref|NP_666216.1| anterior pharynx defective 1A homolog; anterior pharynx defective
1A homolog (C. elegans) [Mus musculus]
gi|15341753|gb|AAH12406.1| Anterior pharynx defective 1A homolog [Mus musculus]
gi|34786036|gb|AAH57865.1| Anterior pharynx defective 1A homolog [Mus musculus]
Length = 247
Score = 165 bits (417), Expect = 1e-39
Identities = 89/247 (36%), Positives = 142/247 (57%), Gaps = 13/247 (5%)
Query: 66 MPLMVFFGCTMIAFGPSLAMFILTIAKYPLKIILLVVGXXXXXXXXXXXXXXXXXVVPLK 125
M VFFGCT +AFGP+ ++F++T+A PL++I+LV G +V +
Sbjct: 1 MGAAVFFGCTFVAFGPAFSLFLITVAGDPLRVIILVAGAFFWLVSLLLASVVWFILVHVT 60
Query: 126 EQ---------LAFSLVFSVIFQEGMRYGLFRMMKNAENGLDDALSEDEKKSISNHKLSY 176
++ L F SV+ QE R+ ++++K A+ GL +LSED + IS +++Y
Sbjct: 61 DRSDARLQYGLLIFGAAVSVLLQEVFRFAYYKLLKKADEGLA-SLSEDGRSPISIRQMAY 119
Query: 177 TTGFGFGLMYGLFSIVNVLSQSIGPGSVGIDGHSSNFMLISAFLTSSTILLHTFWNVIVF 236
+G FG++ G+FS++N+L+ ++GPG VGI G S + L SAFLT++ ILLHTFW V+ F
Sbjct: 120 VSGLSFGIISGVFSVINILADALGPGVVGIHGDSPYYFLTSAFLTAAIILLHTFWGVVFF 179
Query: 237 DALNKQQYYKVITVVCLHMLVSCCSLLNVQQNLAXXXXXXXXXXLIGTTVWAFKAAGGSV 296
DA +++Y+ + VV H+L S + LN + + +WAF AGGS+
Sbjct: 180 DACERRRYWALGLVVGSHLLTSGLTFLNPWYEASLLPIYAVT---VSMGLWAFITAGGSL 236
Query: 297 VNIKSCL 303
+I+ L
Sbjct: 237 RSIQRSL 243
>gi|37077149|sp|Q8BVF7|AP1A_MOUSE Gamma-secretase subunit APH-1A
gi|18848275|gb|AAH24111.1| 6530402N02Rik protein [Mus musculus]
Length = 265
Score = 165 bits (417), Expect = 1e-39
Identities = 89/247 (36%), Positives = 142/247 (57%), Gaps = 13/247 (5%)
Query: 66 MPLMVFFGCTMIAFGPSLAMFILTIAKYPLKIILLVVGXXXXXXXXXXXXXXXXXVVPLK 125
M VFFGCT +AFGP+ ++F++T+A PL++I+LV G +V +
Sbjct: 1 MGAAVFFGCTFVAFGPAFSLFLITVAGDPLRVIILVAGAFFWLVSLLLASVVWFILVHVT 60
Query: 126 EQ---------LAFSLVFSVIFQEGMRYGLFRMMKNAENGLDDALSEDEKKSISNHKLSY 176
++ L F SV+ QE R+ ++++K A+ GL +LSED + IS +++Y
Sbjct: 61 DRSDARLQYGLLIFGAAVSVLLQEVFRFAYYKLLKKADEGLA-SLSEDGRSPISIRQMAY 119
Query: 177 TTGFGFGLMYGLFSIVNVLSQSIGPGSVGIDGHSSNFMLISAFLTSSTILLHTFWNVIVF 236
+G FG++ G+FS++N+L+ ++GPG VGI G S + L SAFLT++ ILLHTFW V+ F
Sbjct: 120 VSGLSFGIISGVFSVINILADALGPGVVGIHGDSPYYFLTSAFLTAAIILLHTFWGVVFF 179
Query: 237 DALNKQQYYKVITVVCLHMLVSCCSLLNVQQNLAXXXXXXXXXXLIGTTVWAFKAAGGSV 296
DA +++Y+ + VV H+L S + LN + + +WAF AGGS+
Sbjct: 180 DACERRRYWALGLVVGSHLLTSGLTFLNPWYEASLLPIYAVT---VSMGLWAFITAGGSL 236
Query: 297 VNIKSCL 303
+I+ L
Sbjct: 237 RSIQRSL 243
>gi|29243936|ref|NP_808251.1| hypothetical protein 4632417K02 [Mus musculus]
gi|37077156|sp|Q8C7N7|AP1B_MOUSE Gamma-secretase subunit APH-1B
gi|26340556|dbj|BAC33940.1| unnamed protein product [Mus musculus]
Length = 257
Score = 161 bits (407), Expect = 2e-38
Identities = 90/247 (36%), Positives = 131/247 (53%), Gaps = 14/247 (5%)
Query: 66 MPLMVFFGCTMIAFGPSLAMFILTIAKYPLKIILLVVGXXXXXXXXXXXXXXXXXVVPLK 125
M VFFGC IAFGP+LA+++ TIA PL++I L+ G V +
Sbjct: 1 MTAAVFFGCAFIAFGPALALYVFTIATDPLRVIFLIAGAFFWLVSLLLSSVFWFLVRVIT 60
Query: 126 EQ---------LAFSLVFSVIFQEGMRYGLFRMMKNAENGLDDALSEDEKKSISNHKLSY 176
+ L F ++ SV QE R ++++K A GL E+ S+ L+Y
Sbjct: 61 DNRDGPVQNYLLIFGVLLSVCIQELFRLAYYKLLKKASEGLKSINPEETAPSM--RLLAY 118
Query: 177 TTGFGFGLMYGLFSIVNVLSQSIGPGSVGIDGHSSNFMLISAFLTSSTILLHTFWNVIVF 236
+G GFG+M G+FS VN LS S+GPG+VGI G S F L SAF+T I+LH FW V+ F
Sbjct: 119 VSGLGFGIMSGVFSFVNTLSNSLGPGTVGIHGDSPQFFLNSAFMTLVVIMLHVFWGVVFF 178
Query: 237 DALNKQQYYKVITVVCLHMLVSCCSLLNVQQNLAXXXXXXXXXXLIGTTVWAFKAAGGSV 296
D K ++Y ++TV+ H++VS + L+ + ++ +WAF AGGS
Sbjct: 179 DGCEKNKWYTLLTVLLTHLVVSTQTFLSPYYEV---NLVTAYIIMVLMGIWAFYVAGGSC 235
Query: 297 VNIKSCL 303
++K CL
Sbjct: 236 RSLKLCL 242
>gi|34864291|ref|XP_217185.2| similar to RIKEN cDNA 0610008A10 [Rattus norvegicus]
Length = 257
Score = 160 bits (406), Expect = 2e-38
Identities = 91/247 (36%), Positives = 132/247 (53%), Gaps = 14/247 (5%)
Query: 66 MPLMVFFGCTMIAFGPSLAMFILTIAKYPLKIILLVVGXXXXXXXXXXXXXXXXXVVPLK 125
M VFFGC IAFGP+LA+++ TIA PL++I L+ G V +
Sbjct: 1 MTAPVFFGCAFIAFGPALALYLFTIATDPLRVIFLIAGAFFWLVSLLLSSVFWFLVRVIT 60
Query: 126 EQ---------LAFSLVFSVIFQEGMRYGLFRMMKNAENGLDDALSEDEKKSISNHKLSY 176
+ L F ++ SV QE R +R++K A GL E+ S+ L+Y
Sbjct: 61 DNRDGPVQNYLLIFGVLLSVCIQELFRLAYYRLLKKASEGLKSINPEETAPSM--RLLAY 118
Query: 177 TTGFGFGLMYGLFSIVNVLSQSIGPGSVGIDGHSSNFMLISAFLTSSTILLHTFWNVIVF 236
+G GFG+M G+FS VN LS ++GPG+VGI G S F L SAF+T I+LH FW ++ F
Sbjct: 119 VSGLGFGIMSGVFSFVNTLSNALGPGTVGIHGDSPQFFLNSAFMTLVIIMLHVFWGIVFF 178
Query: 237 DALNKQQYYKVITVVCLHMLVSCCSLLNVQQNLAXXXXXXXXXXLIGTTVWAFKAAGGSV 296
D K ++Y ++TV+ H+LVS +LL+ + ++ +WAF AGGS
Sbjct: 179 DGCEKNKWYILLTVLLTHLLVSTQTLLSPHYEV---NLVTAYIIMVLMGIWAFCVAGGSR 235
Query: 297 VNIKSCL 303
++K CL
Sbjct: 236 RSLKLCL 242
>gi|31233667|ref|XP_318923.1| ENSANGP00000015809 [Anopheles gambiae]
gi|30174614|gb|EAA14158.2| ENSANGP00000015809 [Anopheles gambiae str. PEST]
Length = 247
Score = 160 bits (405), Expect = 3e-38
Identities = 89/244 (36%), Positives = 139/244 (56%), Gaps = 4/244 (1%)
Query: 62 ILNKMPLMVFFGCTMIAFGPSLAMFILTIAKYPLKIILLVVGXXXXXXXXXXXXXXXXXV 121
+ M ++ FFGC+ +AFGP +AMF LTIA P++II+L+
Sbjct: 3 LARNMTVVEFFGCSFLAFGPPVAMFALTIAHDPIRIIILIAASFFWLVSLLLSSTVWLAF 62
Query: 122 VPLKEQLAFSLVFSVIFQ--EGMRYGLFRMMKNAENGLDDALSEDEKKSISNHKLSYTTG 179
P+ ++ F L+ SV Q + RY ++++++ E+GL + +++ + + H LSY +G
Sbjct: 63 HPVTSKVTFGLICSVFIQVCKRFRYLMYKVLRKTESGLQE-VTDIVRIADYRHILSYASG 121
Query: 180 FGFGLMYGLFSIVNVLSQSIGPGSVGIDGHSSNFMLISAFLTSSTILLHTFWNVIVFDAL 239
GFG++ G FS+VN+L+ S+GP +VG+ S FMLISA + + ILLHTFW+VI F+A
Sbjct: 122 LGFGIISGAFSLVNILADSVGPATVGLKAASDIFMLISAAQSLAMILLHTFWSVIFFNAC 181
Query: 240 NKQQYYKVITVVCLHMLVSCCSLLNVQQNLAXXXXXXXXXXLIGTTVWAFKAAGGSVVNI 299
+ + YY + VV H+ VSC +LLN A I T AF+ AGG+V +
Sbjct: 182 DVKNYYHIGYVVASHLFVSCMTLLNASGLYAVTLLISYTMVCI-TGAIAFQVAGGTVASF 240
Query: 300 KSCL 303
+ L
Sbjct: 241 RKFL 244
>gi|21492616|ref|NP_080950.1| RIKEN cDNA 0610008A10 [Mus musculus]
gi|37077773|sp|Q9DCZ9|AP1C_MOUSE Putative gamma-secretase subunit APH-1C
gi|12832198|dbj|BAB22004.1| unnamed protein product [Mus musculus]
gi|29747906|gb|AAH50923.1| RIKEN cDNA 0610008A10 [Mus musculus]
gi|38648719|gb|AAH63254.1| RIKEN cDNA 0610008A10 [Mus musculus]
Length = 258
Score = 160 bits (405), Expect = 3e-38
Identities = 90/247 (36%), Positives = 132/247 (53%), Gaps = 13/247 (5%)
Query: 66 MPLMVFFGCTMIAFGPSLAMFILTIAKYPLKIILLVVGXXXXXXXXXXXXXXXXXVVPLK 125
M L VFFGC IAFGP+ A+++ TIA PL++I L+ G V +
Sbjct: 1 MTLPVFFGCAFIAFGPAFALYLFTIATDPLRVIFLIAGAFFWLVSLLLSSMFWFLVRVIT 60
Query: 126 EQ---------LAFSLVFSVIFQEGMRYGLFRMMKNAENGLDDALSEDEKKSISNHKLSY 176
L F + SV QE R ++++K A GL +++ +E + S L+Y
Sbjct: 61 NNRDESVQNYLLIFGALLSVCIQELFRLAYYKLLKKASEGLK-SINPEEDIAPSMRLLAY 119
Query: 177 TTGFGFGLMYGLFSIVNVLSQSIGPGSVGIDGHSSNFMLISAFLTSSTILLHTFWNVIVF 236
+G GFG+M G+FS VN LS S+GPG+VGI G S F L SAF+T I+LH FW V+ F
Sbjct: 120 VSGLGFGIMSGVFSFVNTLSNSLGPGTVGIHGDSPQFFLNSAFMTLVVIMLHVFWGVVFF 179
Query: 237 DALNKQQYYKVITVVCLHMLVSCCSLLNVQQNLAXXXXXXXXXXLIGTTVWAFKAAGGSV 296
D K ++Y ++TV+ H++VS + L+ + ++ +WAF AGGS
Sbjct: 180 DGCEKNKWYTLLTVLLTHLVVSTQTFLSPYYEV---NLVTAYIIMVLMGIWAFYVAGGSC 236
Query: 297 VNIKSCL 303
++K CL
Sbjct: 237 RSLKFCL 243
>gi|18088649|gb|AAH20905.1| Presenilin stabilization factor-like [Homo sapiens]
Length = 257
Score = 155 bits (393), Expect = 7e-37
Identities = 92/247 (37%), Positives = 129/247 (52%), Gaps = 14/247 (5%)
Query: 66 MPLMVFFGCTMIAFGPSLAMFILTIAKYPLKIILLVVGXXXXXXXXXXXXXXXXXVVPL- 124
M VFFGC IAFGP+LA+++ TIA PL+II L+ G +
Sbjct: 1 MTAAVFFGCAFIAFGPALALYVFTIATEPLRIIFLIAGAFFWLVSLLISSLVWFMARVII 60
Query: 125 --------KEQLAFSLVFSVIFQEGMRYGLFRMMKNAENGLDDALSEDEKKSISNHKLSY 176
K L F SV QE R+ ++++K A GL + S+ L+Y
Sbjct: 61 DNKDGPTQKYLLIFGAFVSVYIQEMFRFAYYKLLKKASEGLKSINPGETAPSM--RLLAY 118
Query: 177 TTGFGFGLMYGLFSIVNVLSQSIGPGSVGIDGHSSNFMLISAFLTSSTILLHTFWNVIVF 236
+G GFG+M G+FS VN LS S+GPG+VGI G S F L SAF+T ILLH FW ++ F
Sbjct: 119 VSGLGFGIMSGVFSFVNTLSDSLGPGTVGIHGDSPQFFLYSAFMTLVIILLHVFWGIVFF 178
Query: 237 DALNKQQYYKVITVVCLHMLVSCCSLLNVQQNLAXXXXXXXXXXLIGTTVWAFKAAGGSV 296
D K+++ ++ V+ H+LVS + ++ + L+GT WAF AAGGS
Sbjct: 179 DGCEKKKWGILLIVLLTHLLVSAQTFISSYYGI-NLASAFIILVLMGT--WAFLAAGGSC 235
Query: 297 VNIKSCL 303
++K CL
Sbjct: 236 RSLKLCL 242
>gi|37182518|gb|AAQ89061.1| TAAV688 [Homo sapiens]
Length = 257
Score = 155 bits (391), Expect = 1e-36
Identities = 92/247 (37%), Positives = 129/247 (52%), Gaps = 14/247 (5%)
Query: 66 MPLMVFFGCTMIAFGPSLAMFILTIAKYPLKIILLVVGXXXXXXXXXXXXXXXXXVVPL- 124
M VFFGC IAFGP+LA+++ TIA PL+II L+ G +
Sbjct: 1 MTAAVFFGCAFIAFGPALALYVFTIAIEPLRIIFLIAGAFFWLVSLLISSLVWFMARVII 60
Query: 125 --------KEQLAFSLVFSVIFQEGMRYGLFRMMKNAENGLDDALSEDEKKSISNHKLSY 176
K L F SV QE R+ ++++K A GL + S+ L+Y
Sbjct: 61 DNKDGPTQKYLLIFGAFVSVYIQEMFRFAYYKLLKKASEGLKSINPGETAPSM--RLLAY 118
Query: 177 TTGFGFGLMYGLFSIVNVLSQSIGPGSVGIDGHSSNFMLISAFLTSSTILLHTFWNVIVF 236
+G GFG+M G+FS VN LS S+GPG+VGI G S F L SAF+T ILLH FW ++ F
Sbjct: 119 VSGLGFGIMSGVFSFVNTLSDSLGPGTVGIHGDSPQFFLYSAFMTLVIILLHVFWGIVFF 178
Query: 237 DALNKQQYYKVITVVCLHMLVSCCSLLNVQQNLAXXXXXXXXXXLIGTTVWAFKAAGGSV 296
D K+++ ++ V+ H+LVS + ++ + L+GT WAF AAGGS
Sbjct: 179 DGCEKKKWGILLIVLLTHLLVSAQTFISSYYGI-NLASAFIILVLMGT--WAFLAAGGSC 235
Query: 297 VNIKSCL 303
++K CL
Sbjct: 236 RSLKLCL 242
>gi|13775224|ref|NP_112591.1| presenilin stabilization factor-like [Homo sapiens]
gi|37077447|sp|Q8WW43|AP1B_HUMAN Gamma-secretase subunit APH-1B (APH-1b) (Aph-1beta) (Presenilin
stabilization factor-like)
gi|12052866|emb|CAB66606.1| hypothetical protein [Homo sapiens]
gi|24637564|gb|AAN63817.1| presenilin stabilization factor-like protein [Homo sapiens]
Length = 257
Score = 154 bits (389), Expect = 2e-36
Identities = 91/247 (36%), Positives = 129/247 (52%), Gaps = 14/247 (5%)
Query: 66 MPLMVFFGCTMIAFGPSLAMFILTIAKYPLKIILLVVGXXXXXXXXXXXXXXXXXVVPL- 124
M VFFGC IAFGP+LA+++ TIA PL+II L+ G +
Sbjct: 1 MTAAVFFGCAFIAFGPALALYVFTIATEPLRIIFLIAGAFFWLVSLLISSLVWFMARVII 60
Query: 125 --------KEQLAFSLVFSVIFQEGMRYGLFRMMKNAENGLDDALSEDEKKSISNHKLSY 176
K L F SV +E R+ ++++K A GL + S+ L+Y
Sbjct: 61 DNKDGPTQKYLLIFGAFVSVYIREMFRFAYYKLLKKASEGLKSINPGETAPSM--RLLAY 118
Query: 177 TTGFGFGLMYGLFSIVNVLSQSIGPGSVGIDGHSSNFMLISAFLTSSTILLHTFWNVIVF 236
+G GFG+M G+FS VN LS S+GPG+VGI G S F L SAF+T ILLH FW ++ F
Sbjct: 119 VSGLGFGIMSGVFSFVNTLSDSLGPGTVGIHGDSPQFFLYSAFMTLVIILLHVFWGIVFF 178
Query: 237 DALNKQQYYKVITVVCLHMLVSCCSLLNVQQNLAXXXXXXXXXXLIGTTVWAFKAAGGSV 296
D K+++ ++ V+ H+LVS + ++ + L+GT WAF AAGGS
Sbjct: 179 DGCEKKKWGILLIVLLTHLLVSAQTFISSYYGI-NLASAFIILVLMGT--WAFLAAGGSC 235
Query: 297 VNIKSCL 303
++K CL
Sbjct: 236 RSLKLCL 242
>gi|26347159|dbj|BAC37228.1| unnamed protein product [Mus musculus]
Length = 152
Score = 112 bits (281), Expect = 7e-24
Identities = 60/151 (39%), Positives = 93/151 (61%), Gaps = 4/151 (2%)
Query: 153 AENGLDDALSEDEKKSISNHKLSYTTGFGFGLMYGLFSIVNVLSQSIGPGSVGIDGHSSN 212
A+ GL +LSED + IS +++Y +G FG++ G+FS++N+L+ ++GPG VGI G S
Sbjct: 2 ADEGLA-SLSEDGRSPISIRQMAYVSGLSFGIISGVFSVINILADALGPGVVGIHGDSPY 60
Query: 213 FMLISAFLTSSTILLHTFWNVIVFDALNKQQYYKVITVVCLHMLVSCCSLLNVQQNLAXX 272
+ L SAFLT++ ILLHTFW V+ FDA +++Y+ + VV H+L S + LN +
Sbjct: 61 YFLTSAFLTAAIILLHTFWGVVFFDACERRRYWALGLVVGSHLLTSGLTFLNPWYEASLL 120
Query: 273 XXXXXXXXLIGTTVWAFKAAGGSVVNIKSCL 303
+ +WAF AGGS+ +I+ L
Sbjct: 121 PIYAVT---VSMGLWAFITAGGSLRSIQRSL 148
>gi|26324468|dbj|BAC25988.1| unnamed protein product [Mus musculus]
Length = 212
Score = 108 bits (269), Expect = 2e-22
Identities = 62/167 (37%), Positives = 88/167 (52%), Gaps = 11/167 (6%)
Query: 66 MPLMVFFGCTMIAFGPSLAMFILTIAKYPLKIILLVVGXXXXXXXXXXXXXXXXXVVPLK 125
M VFFGC IAFGP+LA+++ TIA PL++I L+ G V +
Sbjct: 1 MTAAVFFGCAFIAFGPALALYVFTIATDPLRVIFLIAGAFFWLVSLLLSSVFWFLVRVIT 60
Query: 126 EQ---------LAFSLVFSVIFQEGMRYGLFRMMKNAENGLDDALSEDEKKSISNHKLSY 176
+ L F ++ SV QE R ++++K A GL E+ S+ L+Y
Sbjct: 61 DNRDGPVQNYLLIFGVLLSVCIQELFRLAYYKLLKKASEGLKSINPEETAPSM--RLLAY 118
Query: 177 TTGFGFGLMYGLFSIVNVLSQSIGPGSVGIDGHSSNFMLISAFLTSS 223
+G GFG+M G+FS VN LS S+GPG+VGI G S F L S +++S
Sbjct: 119 VSGLGFGIMSGVFSFVNTLSNSLGPGTVGIHGDSPQFFLNSVRISAS 165
>gi|34864287|ref|XP_343418.1| similar to RIKEN cDNA 0610008A10 [Rattus norvegicus]
Length = 216
Score = 95.5 bits (236), Expect = 1e-18
Identities = 66/247 (26%), Positives = 102/247 (41%), Gaps = 55/247 (22%)
Query: 66 MPLMVFFGCTMIAFGPSLAMFILTIAKYPLKIILLVVGXXXXXXXXXXXXXXXXXVVPLK 125
M VFFGC IAFGP+L++++ TIA PL++I L+ G V +
Sbjct: 1 MTAAVFFGCAFIAFGPALSLYVFTIATDPLRVIFLIAGAFFWLVSLLLSSVFWFLVRVIT 60
Query: 126 EQ---------LAFSLVFSVIFQEGMRYGLFRMMKNAENGLDDALSEDEKKSISNHKLSY 176
+ L F ++ SV QE R +R++K A GL E+ S+
Sbjct: 61 DNRDGPVQNYLLIFGVLLSVCIQELFRLAYYRLLKKANEGLKSINPEETAPSMR------ 114
Query: 177 TTGFGFGLMYGLFSIVNVLSQSIGPGSVGIDGHSSNFMLISAFLTSSTILLHTFWNVIVF 236
+L AF+T I+LH FW ++ F
Sbjct: 115 -------------------------------------LLAYAFMTLVIIMLHVFWGIVFF 137
Query: 237 DALNKQQYYKVITVVCLHMLVSCCSLLNVQQNLAXXXXXXXXXXLIGTTVWAFKAAGGSV 296
D K ++Y ++TV+ H+LVS +LL+ + ++ +WAF AGGS
Sbjct: 138 DGCEKNKWYILLTVLLTHLLVSTQTLLSPHYEV---NLVTAYIIMVLMGIWAFCVAGGSR 194
Query: 297 VNIKSCL 303
++K CL
Sbjct: 195 RSLKLCL 201
>gi|42661244|ref|XP_375430.1| similar to 60S ribosomal protein L10 (QM protein homolog) [Homo
sapiens]
Length = 153
Score = 89.4 bits (220), Expect = 8e-17
Identities = 37/66 (56%), Positives = 54/66 (81%), Gaps = 1/66 (1%)
Query: 1 ENIKTPLQLYKYLIQCCNKLP-RGPQNHYKHFIRQEYKSHNDETDPERIQEIITRSVENA 59
E ++ PLQLY+YL++CC +LP +G Q HYKH +RQ ++ H+DE +PERIQ+II R++E+A
Sbjct: 83 ELVRRPLQLYRYLLRCCQQLPTKGIQQHYKHAVRQSFRVHSDEDNPERIQQIIKRAIEDA 142
Query: 60 KWILNK 65
WI+NK
Sbjct: 143 DWIMNK 148
>gi|38091510|ref|XP_358407.1| RIKEN cDNA 1810012P15 [Mus musculus]
Length = 100
Score = 88.2 bits (217), Expect = 2e-16
Identities = 37/67 (55%), Positives = 55/67 (82%), Gaps = 1/67 (1%)
Query: 1 ENIKTPLQLYKYLIQCCNKLP-RGPQNHYKHFIRQEYKSHNDETDPERIQEIITRSVENA 59
E ++TPLQLY+YL++CC +LP +G Q HYKH +RQ ++ H+DE + ERIQ+II R++E+A
Sbjct: 8 ELVQTPLQLYRYLLRCCRQLPTKGIQEHYKHAVRQSFQVHSDEDNSERIQQIIKRAIEDA 67
Query: 60 KWILNKM 66
WI+NK+
Sbjct: 68 DWIMNKV 74
>gi|18402667|ref|NP_565724.1| expressed protein [Arabidopsis thaliana]
gi|37077331|sp|Q8L9G7|APH1_ARATH Gamma-secretase subunit APH1-like
gi|17381290|gb|AAL36063.1| At2g31440/T28P16.7 [Arabidopsis thaliana]
gi|20198156|gb|AAD26475.2| unknown protein [Arabidopsis thaliana]
gi|20453379|gb|AAM19928.1| At2g31440/T28P16.7 [Arabidopsis thaliana]
Length = 250
Score = 79.3 bits (194), Expect = 9e-14
Identities = 53/207 (25%), Positives = 98/207 (47%), Gaps = 8/207 (3%)
Query: 66 MPLMVFFGCTMIAFGPSLAMFILTIAKYPLKIILLVVGXXXXXXXXXXXXXXXXXVVPLK 125
M + G ++A GPSL++F+ I++ P I+ ++ +PLK
Sbjct: 1 MTVAAGIGYALVALGPSLSLFVSVISRKPFLILTVLSSTLLWLVSLIILSGLWRPFLPLK 60
Query: 126 EQL----AFSLVFSVIFQEGMRYGLFRMMKNAENGLD---DALSEDEKKSISNHKLSYTT 178
+ A ++ SV FQEG+R+ +++ K E+ LD D +S +++
Sbjct: 61 ANVWWPYALLVITSVCFQEGLRFLFWKVYKRLEDVLDSFADRISRPRLFLTDKLQIALAG 120
Query: 179 GFGFGLMYGLFSIVNVLSQSIGPGSVGIDGHSS-NFMLISAFLTSSTILLHTFWNVIVFD 237
G G G+ + +F +++L+ + GP + ++ S F LISA + + + +HTF VI F+
Sbjct: 121 GLGHGVAHAVFFCLSLLTPAFGPATFYVERCSKVPFFLISAIIALAFVTIHTFSMVIAFE 180
Query: 238 ALNKQQYYKVITVVCLHMLVSCCSLLN 264
K I V +H+ +L+N
Sbjct: 181 GYAKGNKVDQIIVPVIHLTAGMLTLVN 207
>gi|21594204|gb|AAM65980.1| unknown [Arabidopsis thaliana]
Length = 250
Score = 79.0 bits (193), Expect = 1e-13
Identities = 53/207 (25%), Positives = 98/207 (47%), Gaps = 8/207 (3%)
Query: 66 MPLMVFFGCTMIAFGPSLAMFILTIAKYPLKIILLVVGXXXXXXXXXXXXXXXXXVVPLK 125
M + G ++A GPSL++F+ I++ P I+ ++ +PLK
Sbjct: 1 MTVAAGIGYALVALGPSLSLFVSVISRKPFLILTVLSSTLLWLVSLIILSGLWRPFLPLK 60
Query: 126 EQL----AFSLVFSVIFQEGMRYGLFRMMKNAENGLD---DALSEDEKKSISNHKLSYTT 178
+ A ++ SV FQEG+R+ +++ K E+ LD D +S +++
Sbjct: 61 ANVWWPYAVLVITSVCFQEGLRFLFWKVYKRLEDVLDSFADRISRPRLFLTDKLQIALAG 120
Query: 179 GFGFGLMYGLFSIVNVLSQSIGPGSVGIDGHSS-NFMLISAFLTSSTILLHTFWNVIVFD 237
G G G+ + +F +++L+ + GP + ++ S F LISA + + + +HTF VI F+
Sbjct: 121 GLGHGVAHAVFFCLSLLTPAFGPATFYVERCSKVPFFLISAIIALAFVTIHTFSMVIAFE 180
Query: 238 ALNKQQYYKVITVVCLHMLVSCCSLLN 264
K I V +H+ +L+N
Sbjct: 181 GYAKGNKVDQIIVPVIHLTAGMLTLVN 207
>gi|39580694|emb|CAE70374.1| Hypothetical protein CBG16933 [Caenorhabditis briggsae]
Length = 1387
Score = 68.6 bits (166), Expect = 2e-10
Identities = 59/246 (23%), Positives = 104/246 (42%), Gaps = 27/246 (10%)
Query: 45 PERIQEIITRSVENAKWILNKMPLMVFFGCTMIAFGPSLAMFILTIAKYPLKIILLVVGX 104
P I + + R + KM +++ C + +F PS+A+F IA P++IIL +G
Sbjct: 1052 PLYIVKALRRKFSPPSYAKIKMGIVLTVSCYIASFSPSIALFYSFIAHDPVRIILFFLGS 1111
Query: 105 XXXXXXXXXXXXXXXXV-VPLKEQLAFSLVFSVIFQEGMRYGLFRMMKNAENGLDDALSE 163
+ L SL ++ QE R F ++K A+ GL + ++
Sbjct: 1112 FFWLVSLLISSLAWLGLSTVLPNTFLISLGVCIVAQELSRVAYFMLLKKAQKGL-NKITR 1170
Query: 164 DEKKSI---------SNHKLSYTTGFGFGLMYGLFSIVNVLSQSIGPGSVG--------- 205
+ S+ + H L+ G G G++ LF +N + GPG++G
Sbjct: 1171 HGQISVAPGVSDLHNARHMLALVCGLGMGVISALFYTMNAFATFAGPGTIGLPMALETGH 1230
Query: 206 IDGHSSNFMLISAFLTSSTI--LLHTFWNVIVFDALNKQQYYKVITV-----VCLHMLVS 258
ID + + L ++ S+ + L H W ++V+D +K + V V H+ V+
Sbjct: 1231 IDSNRAGKYLPLCYVLSAILLTLFHVAWTIMVWDTCHKIGRFPTAFVPGAAAVVSHLFVA 1290
Query: 259 CCSLLN 264
S LN
Sbjct: 1291 FLSSLN 1296
>gi|17509423|ref|NP_492469.1| i-78 protein like, Anterior PHarynx defective APH-1, Presenilin
ENhancer (enhancer of sel-12 null) PEN-1 (aph-1)
[Caenorhabditis elegans]
gi|37076812|sp|O45876|APH1_CAEEL Gamma-secretase subunit aph-1 (Anterior-pharynx-defective protein
1) (Presenilin enhancer protein 1)
gi|7508722|pir||T26007 hypothetical protein VF36H2L.1 - Caenorhabditis elegans
gi|3880371|emb|CAA16282.1| C. elegans APH-1 protein (corresponding sequence VF36H2L.1)
[Caenorhabditis elegans]
Length = 308
Score = 67.8 bits (164), Expect = 3e-10
Identities = 55/224 (24%), Positives = 94/224 (41%), Gaps = 25/224 (11%)
Query: 66 MPLMVFFGCTMIAFGPSLAMFILTIAKYPLKIILLVVGXXXXXXXXXXXXXXXXXV-VPL 124
M ++ C + +F PS+A+F IA P++IIL +G + L
Sbjct: 1 MGYLLTIACYIASFSPSIALFCSFIAHDPVRIILFFLGSFFWLVSLLFSSLAWLGLSTVL 60
Query: 125 KEQLAFSLVFSVIFQEGMRYGLFRMMKNAENGLDDALSEDEKKSI--------SNHKLSY 176
+ SL +I QE R F ++K A+ GL+ + + + H L+
Sbjct: 61 PDTFLLSLTVCIIAQELSRVAYFMLLKKAQRGLNKITRQGQISVAPGVSDLHNARHMLAL 120
Query: 177 TTGFGFGLMYGLFSIVNVLSQSIGPGSVG---------IDGHSSNFMLISAFLTSSTI-- 225
G G G++ LF +N + GPG++G ID + + L + S+ +
Sbjct: 121 VCGLGMGVISALFYTMNAFAIFSGPGTIGLPNALKTGEIDTNRAGKYLPLCYTLSAILLT 180
Query: 226 LLHTFWNVIVFDALNK-----QQYYKVITVVCLHMLVSCCSLLN 264
L H W ++V+D+ +K + V H+LV+ S LN
Sbjct: 181 LFHVTWTIMVWDSCHKIGRIPSAFVPGAAAVVSHLLVTFLSSLN 224
>gi|20829201|ref|XP_129583.1| similar to CGI-78 protein [Mus musculus]
Length = 94
Score = 50.8 bits (120), Expect = 3e-05
Identities = 20/38 (52%), Positives = 30/38 (78%)
Query: 66 MPLMVFFGCTMIAFGPSLAMFILTIAKYPLKIILLVVG 103
M VFFGCT +AFGP+ ++F++T+A PL++I+LV G
Sbjct: 1 MGAAVFFGCTFVAFGPAFSLFLITVAGDPLRVIILVAG 38
Database: All non-redundant GenBank CDS
translations+PDB+SwissProt+PIR+PRF excluding environmental samples
Posted date: May 11, 2004 12:59 AM
Number of letters in database: 593,787,773
Number of sequences in database: 1,798,171
Lambda K H
0.325 0.140 0.418
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 303,827,620
Number of Sequences: 1798171
Number of extensions: 10713352
Number of successful extensions: 32628
Number of sequences better than 1.0e-03: 26
Number of HSP's better than 0.0 without gapping: 22
Number of HSP's successfully gapped in prelim test: 4
Number of HSP's that attempted gapping in prelim test: 32558
Number of HSP's gapped (non-prelim): 27
length of query: 303
length of database: 593,787,773
effective HSP length: 125
effective length of query: 178
effective length of database: 369,016,398
effective search space: 65684918844
effective search space used: 65684918844
T: 11
A: 40
X1: 15 ( 7.0 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 40 (21.6 bits)
S2: 108 (46.2 bits)